MULTI-STRAIN MODELING OF INFLUENZA VACCINE EFFECTIVENESS IN OLDER ADULTS AND ITS DEPENDENCE ON ANTIGENIC DISTANCE

Multi-strain modeling of influenza vaccine effectiveness in older adults and its dependence on antigenic distance

Abstract Influenza vaccine effectiveness (VE) varies seasonally due to host, virus and vaccine characteristics.To investigate how antigenic matching and dosage impact VE, we developed a mechanistic knowledge-based mathematical model.Immunization with a split vaccine is modeled for exposure to A/H1N1 or A/H3N2 virus strains.The model accounts for cr

read more


Which is the optimal fiscal rule in a monetary union? Targeting the structural, the global budgetary deficit, or the public debt?

The aim of our paper is to contribute to the debate on optimal fiscal rules in a monetary union: in terms of global budgetary deficit, of structural budgetary deficit, or of public debt.Indeed, these rules seem to be mixed in the framework of the European Economic and Monetary Union, with the new Fiscal Compact.With the help of a simple macroeconom

read more