Multi-strain modeling of influenza vaccine effectiveness in older adults and its dependence on antigenic distance
Abstract Influenza vaccine effectiveness (VE) varies seasonally due to host, virus and vaccine characteristics.To investigate how antigenic matching and dosage impact VE, we developed a mechanistic knowledge-based mathematical model.Immunization with a split vaccine is modeled for exposure to A/H1N1 or A/H3N2 virus strains.The model accounts for cr